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Are 3D mammograms better than standard imaging? A diverse study aims to find out_我的网站

律政英雄

一 |     Are 3D mammograms better than standard 2D imaging for catching advanced cancers?A clinical trial is recruiting thousands of volunteers — including a large number of Black women who face disparities in breast cancer death rates — to try to find out.People like Carole Stovall, a psychologist in Washington, D.C., have signed up for the study to help answer the question.“We all need a mammogram anyway, so why not do it with a study that allows the scientists to understand more and move closer to finding better treatments and ways of maybe even preventing it?” Stovall said.The underrepresentation of women and minorities in research is a long-simmering issue affecting health problems including Alzheimer’s disease, stroke and COVID-19. Trials without diversity lead to gaps in understanding of how new treatments work for all people. “Until we get more Black women into clinical trials, we can’t change the science. And we need better science for Black bodies,” said Ricki Fairley, a breast cancer survivor and advocate who is working on the issue.Black women are 40% more likely to die from breast cancer than white women and tend to be diagnosed younger. But it’s not clear whether 3D mammography is better for them, said Dr. Worta McCaskill-Stevens of the National Cancer Institute.“Are there populations for whom this might be important to have early diagnosis?" asked McCaskill-Stevens. "Or is it harmful,” causing too many false alarms or unneeded follow-up tests and treatments?McCaskill-Stevens, who is Black, leads NCI’s efforts to boost access to cancer research in minority and rural communities. She has joined the study herself.The newer 3D technique has been around for a decade, but there’s never been conclusive evidence that it's better than 2D at detecting advanced cancers. The screening technique combines multiple pictures of the breast taken from different angles to create a 3D-like image. Both 3D and 2D mammograms compress the breast and use low doses of radiation.Prior studies suggest that 3D finds more cancers than 2D, but catching more cancers doesn’t necessarily mean more lives saved. Some cancers missed by standard screening may not progress or need treatment. Previous studies did not randomly assign patients to a screening method, the gold standard for research.The notion “that if it’s new, it’s shiny, then it’s better,” isn’t necessarily true, McCaskill-Stevens said. “Until we have the evidence to support that, then we need well-designed randomized trials.”The trial has enrolled nearly 93,000 women so far with a goal of 128,000. The NCI-funded study is now running in Canada, South Korea, Peru, Argentina, Italy and 32 U.S. states. A site in Thailand will soon begin enrolling patients.“We added more international sites to enhance the trial’s diversity, particularly for Hispanic and Asian women,” said Dr. Etta Pisano, who leads the study. Overall, 42% of participants are Hispanic. As recruiting continues, enrolling Black women and other women of color will “absolutely” continue as a priority, Pisano said.Participants are randomly assigned to either 2D or 3D mammograms and are followed for several years. The number of advanced cancers detected by the two methods will be compared.At the U.S. study sites, 21% of study participants are Black women — that's higher than a typical cancer treatment study, in which 9% of participants are Black, McCaskill-Stevens said.The University of North Carolina has signed up more Black women than any other study site. Nearly a quarter of the nearly 3,000 women enrolled at UNC’s two locations are Black.“Women in North Carolina want to take part in something that’s bigger than them,” said Dr. Cherie Kuzmiak, who leads the UNC arm of the study. “They want this active role in helping determine the future of health care for women.”In Washington, D.C., word of mouth has led to successful recruiting. A chance encounter at her hair salon persuaded Stovall to join the research. While waiting for a hair appointment, she met Georgetown University cancer researcher Lucile Adams-Campbell. The two, both Black, started chatting.“She explained how important it was to get women of color into the program,” said Stovall, who jumped at the chance to catch up on her mammograms after the COVID-19 pandemic delayed screening for her and thousands of others.For Stovall, there was a personal reason to join the research. Her sister recently completed treatment for triple negative breast cancer, an aggressive type that affects Black women at higher rates than white women. Women ages 45 to 74 without a personal history of breast cancer are eligible for the study, which launched in 2017. Many women also are providing blood and cheek swab samples for a database that will be mined for insights.“It’s a dream that people had since the beginning of screening that we wouldn’t fit everybody into the same box,” Pisano said. The study's findings could “reduce disparities if we’re successful, assuming people have access to care.”Stovall, 72, had a brief scare when her mammogram, the traditional 2D type, showed something suspicious. A biopsy ruled out cancer.“I was extremely relieved,” Stovall said. “Everybody I know has heard from me about the need for them to go get a mammogram.”___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.。

二 |     更新下有关威少的新闻,这次很不错。近日,威少接受了美国媒体的专访,记者问威少:你现在是一名自由球员,很多人都想知道你下一站会去哪里,你怎么看待这个问题?威少的回答是:老实说,我还没有想太多,你问我明年还想不想打?当然想,我热爱篮球,如果有机会继续打球,我会抓住它,这就是我的计划。         与此同时,ESPN名记Anthony Slater也撰文谈到了威少的处境,其表示,国王有意续约威少,但需要其转变角色,相关原文如下:          过去这一年里,威斯布鲁克已经明确表示,在自己打完第18个NBA赛季后,并无退役打算,因此,他仍在寻找合适的契机,以延续自己的职业生涯。         他最近效力的国王,据球队多位消息人士透露,仍对重聚持开放态度,但也理解威少可能不太愿意在备受瞩目的新秀阿卡夫身后担任缩减后的角色。

三 |          国王总经理斯科特佩里承认,上赛季威斯布鲁克的表现“超出了”国王所能提供的底薪合同的价值,同时为国王阵中的年轻球员担任了宝贵的导师角色。         威斯布鲁克显然没有紧迫的时间表,这与去年夏天类似——当时他也在权衡各种选择,直到10月初训练营开始前才同意加盟国王。

四 |          有一说一,国王总经理所言并非虚假。         上赛季,威少的表现确实超出底薪,他一共出战了64场比赛,其中58场首发,场均上场28.9分钟,得到15.2分5.4篮板6.7助攻1.3抢断,三项命中率42.7%/33.8%/69.4%,真实命中率52.8%。         需要说的是,威少一开始签下的只是一份非保障底薪,当时国王给他的定位是替补,首发是3年4000万签下的施罗德,结果没打多久,威少就把施罗德挤下了首发。

五 |          以及很重要的一点,在威少的帮助下,国王去年的二轮秀中锋雷诺打出了远超顺位的表现,场均可以拿到12.5分7.5篮板1.4助攻,入选了最佳新秀二阵——          这个真的不是强行夸,威少是上赛季国王全队最会给雷诺传球、也是传球和助攻次数最多的球员,而且几乎断档领先的那种。         肯定的一点,威少的油箱里绝对有油。         但问题也很明显,就像记者们所报道的,国王可能有意续约威少,前提是威少能够接受更低的角色,比如,给阿卡夫打替补。

六 |          这个可就跟施罗德不一样了,阿卡夫是今年的首轮第7顺位,绝对是国王的重点培养对象,即便第一年打得不理想,他能得到的球权也会远超威少。         其实吧,威少也不是没有打过替补,此前在掘金,威少就是球队的第六人,可惜的是,那一年结果并不理想,掘金最终次轮不敌雷霆出局。         不过留在国王是另外一种情况——掘金好歹是争冠球队,但国王是重建球队,如果续约国王的话,基本可以确定,威少下赛季没有机会夺冠了。         而且吧,个人觉得,威少的场均上场时间可能会骤减到15分钟左右,几乎是他上赛季的一半,数据也会相应减少。         最终,不妨整理下威少今夏的一些流言时间线:          ——先是国王有意续约威少          ——然后又有消息说奇才有意          ——期间与热火、火箭也传出过绯闻          ——再者是国王无意续约威少,威少可能前往欧洲          ——最后就是国王又有意续约威少…          讲真,流言有点太过混乱了,不同记者报道的都不一样,单是国王,就出现了愿意续约、不愿意续约、愿意续约的多条消息,真实性存疑。         不过可以肯定的一点是,从最新的采访来看,威少暂时还没有退役的想法,这位前MVP依然希望继续在NBA打球。         纯个人观点,威少应该会得到一份合同,不过要等到10月份,就像上赛季一样,而且个人感觉不会是国王,在威少愿意接受更低角色的情况下,他的选择会很多,但这几年确实是威少生涯的尾巴了,且看且珍惜。

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Published on:21:12:15


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